Targeting immune dysfunction in aging

Human aging is a multifactorial phenomenon that affects numerous organ systems and cellular processes, with the immune system being one of most dysregulated. Immunosenescence, gradual deterioration system, inflammaging, chronic inflammatory state persists in elderly, are among plethora changes occur during aging. Almost all populations cells change age terms numbers and/or activity. These alterations general highly detrimental, resulting an increased susceptibility to infections, reduced healing abilities, altered homeostasis promote emergence age-associated diseases such as cancer, diabetes, other associated inflammation. Thanks recent developments, several strategies have been proposed target central immunological processes or specific subpopulations affected by therapeutic approaches could soon be applied clinic slow down even reverse age-induced order rejuvenate prevent reduce impact various diseases. Due its systemic nature interconnection body, attractive for intervention because relatively targeted modifications small set potential improve health multiple systems. Therefore, anti-aging targeting therapies represent potent approach improving healthspan. Here, we review major components summarize current immune-targeting context discuss future directions field rejuvenation.